SLO3 K+ Channels Control Calcium Entry through CATSPER Channels in Sperm
نویسندگان
چکیده
منابع مشابه
Calcium signaling through CatSper channels in mammalian fertilization.
The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and ...
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The mouse Slo3 gene (KCNMA3) encodes a K(+) channel that is regulated by changes in cytosolic pH. Like Slo1 subunits responsible for the Ca(2+) and voltage-activated BK-type channel, the Slo3 alpha subunit contains a pore module with homology to voltage-gated K(+) channels and also an extensive cytosolic C terminus thought to be responsible for ligand dependence. For the Slo3 K(+) channel, incr...
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Following entry into the female reproductive tract, mammalian sperm undergo a maturation process termed capacitation that results in competence to fertilize ova. Associated with capacitation is an increase in membrane conductance to both Ca(2+) and K(+), leading to an elevation in cytosolic Ca(2+) critical for activation of hyperactivated swimming motility. In mice, the Ca(2+) conductance (alka...
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Introduction: Cinnamon is a plant containing anti-inflammatory, anti-apoptotic, and antioxidant substances. Previous studies have revealed the reducing effects of obesity and hyperlipidemia and, on the contrary, the reinforcing effects of cinnamon on fertility. Therefore in this study the effect of the hydroalcoholic extract of cinnamon on Body Mass Index (BMI) and gene expression of cation cha...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.607556